systems.bio

Bebek Lab, Case Western Reserve University

GurkanBebek_headshot.webp

Gürkan Bebek, PhD, MS

2109 Adelbert Rd

BRB 921

Cleveland, OH 44106

U.S.A.

Welcome to the home page for Dr. Gurkan Bebek and Bebek Lab, where we develop systems biology algorithms and methods to analyze and integrate large omic datasets. We study complex phenotypes to address problems about human health and diseases.

Our research highlights include significant projects such as cancer drug response networks, causal regulatory network analysis, and recent advances in understanding heterogeneity in Alzheimer’s disease. We have published over 50 peer-reviewed articles. Our work spans various domains, including proteomics, genomics, metagenomics, epigenetics, pharmacogenomics, and clinical informatics.

Meet our team of dedicated researchers. Each member brings unique expertise to our lab, contributing to our mission of advancing medical research. Stay updated with our latest news, achievements, and upcoming events. Feel free to connect with us through our social media links and contact information provided below.

news

May 01, 2026 Submit your paper to AI-Integrated Multi-Omics for Neurodegeneration: Mechanistic Insights to Clinical Innovation. Manuscript Submission Deadline 29 October 2026 :pencil2:
Mar 31, 2026 Submit your paper to PSB 2027 Session on Systems Biology and Network Analysis From Multi-omics Integration to Biological Mechanism. [Deadline: August 1] :pencil2: :tropical_fish:
Dec 08, 2025 SYBB 464 - AI for Bioimedical Research is now offered in the Spring. Register soon! :sparkles: :school:
May 17, 2025 See papers from our PSB 2026 Session on Systems Biology and Network Analysis From Multi-omics Integration to Biological Mechanism. :pencil2: :tropical_fish:
May 17, 2025 Protein Co-Aggregates Differ in Rapid vs. Sporadic Alzheimer’s Disease Paper is accepted for publication in Alzheimer’s Research and Therapy. :sparkles: :page_facing_up:

latest posts

Apr 15, 2026 The Illusion of Perfection
Nov 05, 2025 Bridging the Gap: Why AI and Biology Must Learn from Each Other
Jul 09, 2025 Don't Waste Your Science: A Practical Guide to Statistical Power

selected publications

  1. Human alveolar macrophages display marked hypo-responsiveness to IFN-γin both proteomic and gene expression analysis
    Bonnie A Thiel, Kathleen C Lundberg, Daniela Schlatzer, and 8 more authors
    Plos one, 2024
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  2. CSF immune cell phenotypes and their related pathway activation differ by Alzheimers disease stage compared to normal controls
    Gurkan Bebek, Ziyin Zhao, Mi-Hyun Hwang, and 2 more authors
    In Alzheimer’s Association International Conference , 2024
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