Systems Biology and Network Analysis

Motivation

Recent technological advancements have generated unprecedented amounts of multi-omics data, creating significant opportunities to deepen our understanding of complex biological systems. This session aims to highlight cutting-edge computational methods for systems-level analysis, focusing on novel approaches for gene regulatory network inference, metabolic pathway modeling, and the integration of diverse omics datasets. By decoding the intricate interplay between molecular components and their roles in biological mechanisms, we aim to advance our knowledge in critical areas such as disease mechanisms, toxicity, and other essential biological processes. This session bridges the gap between precision medicine and fundamental biological understanding, complementing other PSB sessions and fostering synergies with AI/ML and precision medicine approaches.

Session Topics

We welcome submissions that advance our ability to analyze and interpret complex biological systems. Specific areas of interest include, but are not limited to:

• Novel approaches to gene regulatory network inference
• Metabolic pathway modeling and analysis
• Multi-omics data integration methods
• Methods bridging different biological scales (molecular to tissue-level)
• Integration of network biology with machine learning for hypothesis generation
• Application of non-biological networks to understand biological and behavioral phenomena
• Analysis of single-cell multi-omics data with network biology
• Spatial transcriptomics and its integration with network biology
• Graph neural networks for biological network inference
• Time-resolved network analysis of dynamic biological processes
• Network-based methods for drug repurposing and combination therapy prediction

Session Organizers

Paper Submissions

Unlike the abstracts at most biology conferences, papers in the PSB proceedings are archival, rigorously peer-reviewed publications. PSB publications are Open Access and linked directly from MEDLINE/PubMed and Google Scholar for wide accessibility. They should be thought of as short journal articles that may be cited on CVs and grant reports.

Authors are invited to submit original research contributions for consideration. Submissions will undergo a rigorous peer-review process. PSB accepts submissions for full-length papers.

Papers should be formatted according to the guidelines provided on the official PSB 2026 website. Please see the PSB paper format template and submission instructions.