systems.bio

Bebek Lab, Case Western Reserve University

GurkanBebek_headshot.jpg

Gürkan Bebek, PhD, MS

2109 Adelbert Rd

BRB 921

Cleveland, OH 44106

U.S.A.

Welcome to the home page for Dr. Gurkan Bebek and Bebek Lab, where we develop systems biology algorithms and methods to analyze and integrate large omic datasets. We study complex phenotypes to address problems about human health and diseases.

Our research highlights include significant projects such as cancer drug response networks, causal regulatory network analysis, and recent advances in understanding heterogeneity in Alzheimer’s disease. We have published over 50 peer-reviewed articles. Our work spans various domains, including proteomics, genomics, metagenomics, epigenetics, pharmacogenomics, and clinical informatics.

Meet our team of dedicated researchers. Each member brings unique expertise to our lab, contributing to our mission of advancing medical research. Stay updated with our latest news, achievements, and upcoming events. Feel free to connect with us through our social media links and contact information provided below.

news

May 17, 2025 Submit your paper to PSB 2026 Session on Systems Biology and Network Analysis From Multi-omics Integration to Biological Mechanism. :pencil2: :tropical_fish:
May 17, 2025 Protein Co-Aggregates Differ in Rapid vs. Sporadic Alzheimer’s Disease Paper is accepted for publication in Alzheimer’s Research and Therapy. :sparkles: :page_facing_up:
Dec 15, 2024 SYBB 402 is now offered as an online asynchronous class. Register soon! :sparkles: :school:
Mar 12, 2024 Our paper, “CADRE: Utilizing CAncer Drug Response nEtwork for Drug Synergy Prediction,” is accepted for oral presentation at RECOMB-CCB 2024! 🎉 Looking forward to the event in Boston, MA, on April 27-28, 2024.
Oct 22, 2023 Our new website is live on systems.bio !

latest posts

May 17, 2025 Distinct Proteomic Signatures in Rapidly Progressive Alzheimer's Disease
Apr 25, 2025 Seed-Guided Subnetwork Discovery in Disease Mechanisms
Apr 01, 2025 Call for Papers: Systems Biology and Network Analysis at PSB 2026

selected publications

  1. Human alveolar macrophages display marked hypo-responsiveness to IFN-γin both proteomic and gene expression analysis
    Bonnie A Thiel, Kathleen C Lundberg, Daniela Schlatzer, and 8 more authors
    Plos one, 2024
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  2. CSF immune cell phenotypes and their related pathway activation differ by Alzheimers disease stage compared to normal controls
    Gurkan Bebek, Ziyin Zhao, Mi-Hyun Hwang, and 2 more authors
    In Alzheimer’s Association International Conference , 2024
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